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Anticancer Discovery from Pets to People

To view the full list of publications across IGB's research portfolio, please visit our Illinois Experts page

2023

Geddes, E. J., Gugger, M., Garcia, A., Garcia Chavez, M., Lee, M. R., Perlmutter, S. J., Bieniossek, C., Guasch, L., & Hergenrother, P. (2023). Porin-independent accumulation in Pseudomonas enables antibiotic discovery. Nature, 624(7990), 145-153. https://doi.org/10.1038/s41586-023-06760-8

Boudreau, M. W., Tonogai, E. J., Schane, C. P., Xi, M. X., Fischer, J. H., Vijayakumar, J., Ji, Y., Tarasow, T. M., Fan, T. M., Hergenrother, P. J., & Dudek, A. Z. (2023). The combination of PAC-1 and entrectinib for the treatment of metastatic uveal melanoma. Melanoma research, 33(6), 514-524. https://doi.org/10.1097/CMR.0000000000000927

Yu, L., Xu, L., Chu, H., Peng, J., Sacharidou, A., Hsieh, H. H., Weinstock, A., Khan, S., Ma, L., Durán, J. G. B., McDonald, J., Nelson, E. R., Park, S., McDonnell, D. P., Moore, K. J., Huang, L. J. S., Fisher, E. A., Mineo, C., Huang, L., & Shaul, P. W. (2023). Macrophage-to-endothelial cell crosstalk by the cholesterol metabolite 27HC promotes atherosclerosis in male mice. Nature communications, 14(1), Article 4101. https://doi.org/10.1038/s41467-023-39586-z

Maji, A., Soutar, C. P., Zhang, J., Lewandowska, A., Uno, B. E., Yan, S., Shelke, Y., Murhade, G., Nimerovsky, E., Borcik, C. G., Arango, A. S., Lange, J. D., Marin-Toledo, J. P., Lyu, Y., Bailey, K. L., Roady, P. J., Holler, J. T., Khandelwal, A., SantaMaria, A. M., ... Burke, M. D. (2023). Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal. Nature, 623(7989), 1079-1085. https://doi.org/10.1038/s41586-023-06710-4

Ghosh, S., Yang, R., Duraki, D., Zhu, J., Kim, J. E., Jabeen, M., Mao, C., Dai, X., Livezey, M. R., Boudreau, M. W., Park, B. H., Nelson, E. R., Hergenrother, P. J., & Shapiro, D. J. (2023). Plasma Membrane Channel TRPM4 Mediates Immunogenic Therapy–Induced Necrosis. Cancer Research, 83(18), 3115-3130. https://doi.org/10.1158/0008-5472.CAN-23-0157

Gapinske, M., Winter, J., Swami, D., Gapinske, L., Woods, W. S., Shirguppe, S., Miskalis, A., Busza, A., Joulani, D., Kao, C. J., Kostan, K., Bigot, A., Bashir, R., & Perez-Pinera, P. (2023). Targeting Duchenne muscular dystrophy by skipping DMD exon 45 with base editors. Molecular Therapy - Nucleic Acids, 33, 572-586. https://doi.org/10.1016/j.omtn.2023.07.029

Gordon, D. L., Foreman, J. H., Connolly, S. L., Schnelle, A. N., Fan, T. M., & Barger, A. M. (2023). Acute phase protein concentrations following serial procaine penicillin G injections in horses. Equine veterinary journal, 55(5), 916-922. https://doi.org/10.1111/evj.13886

Corbet, A. K., Bikorimana, E., Boyd, R. I., Shokry, D., Kries, K., Gupta, A., Paton, A., Sun, Z., Fazal, Z., Freemantle, S. J., Nelson, E. R., Spinella, M. J., & Singh, R. (2023). G0S2 promotes antiestrogenic and pro-migratory responses in ER+ and ER- breast cancer cells. Translational Oncology, 33, Article 101676. https://doi.org/10.1016/j.tranon.2023.101676

Baur, B., Shin, J., Schreiber, J., Zhang, S., Zhang, Y., Manjunath, M., Song, J. S., Noble, W. S., & Roy, S. (2023). Leveraging epigenomes and three-dimensional genome organization for interpreting regulatory variation. PLoS computational biology, 19(7), Article e1011286. https://doi.org/10.1371/journal.pcbi.1011286

Stinson, J. A., Sheen, A., Momin, N., Hampel, J., Bernstein, R., Kamerer, R., Fadl-Alla, B., Samuelson, J., Fink, E., Fan, T. M., & Wittrup, K. D. (2023). Collagen-Anchored Interleukin-2 and Interleukin-12 Safely Reprogram the Tumor Microenvironment in Canine Soft-Tissue Sarcomas. Clinical Cancer Research, 29(11), 2110-2122. https://doi.org/10.1158/1078-0432.CCR-23-0006

Ranoa, D. R. E., Sharma, P., Schane, C. P., Lewis, A. N., Valdez, E., Marada, V. V. V. R., Hager, M. V., Montgomery, W., Wolf, S. P., Schreiber, K., Schreiber, H., Bailey, K., Fan, T. M., Hergenrother, P. J., Roy, E. J., & Kranz, D. M. (2023). Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model. Journal for ImmunoTherapy of Cancer, 11(5), Article e006509. https://doi.org/10.1136/jitc-2022-006509

Anmangandla, A., Jana, S., Peng, K., Wallace, S. D., Bagde, S. R., Drown, B. S., Xu, J., Hergenrother, P. J., Fromme, J. C., & Lin, H. (2023). A Fluorescence Polarization Assay for Macrodomains Facilitates the Identification of Potent Inhibitors of the SARS-CoV-2 Macrodomain. ACS chemical biology, 18(5), 1200-1207. https://doi.org/10.1021/acschembio.3c00092

Miller, J. C., Lee, J. H. Z., Mclean, M. A., Chao, R. R., Stone, I. S. J., Pukala, T. L., Bruning, J. B., De Voss, J. J., Schuler, M. A., Sligar, S. G., & Bell, S. G. (2023). Engineering C-C Bond Cleavage Activity into a P450 Monooxygenase Enzyme. Journal of the American Chemical Society, 145(16), 9207-9222. https://doi.org/10.1021/jacs.3c01456

Putt, K. S., Tarasow, T., Sandhorst, J. S., Hergenrother, P. J., Fako, V. E., & Peterson, Q. P. (2023). Compounds And Methods For The Treatment Of Cancer. (U.S. Patent No. 11612598).

Danciu, O. C., Holdhoff, M., Peterson, R. A., Fischer, J. H., Liu, L. C., Wang, H., Venepalli, N. K., Chowdhery, R., Nicholas, M. K., Russell, M. J., Fan, T. M., Hergenrother, P. J., Tarasow, T. M., & Dudek, A. Z. (2023). Phase I study of procaspase-activating compound-1 (PAC-1) in the treatment of advanced malignancies. British Journal of Cancer, 128(5), 783-792. https://doi.org/10.1038/s41416-022-02089-7

Hergenrother, P. J., Shapiro, D. J., & Boudreau, M. W. (2023). Activators Of The Unfolded Protein Response. (U.S. Patent No. 11584718).

Kwon, J. Y., Moskwa, N., Kang, W., Fan, T. M., & Lee, C. (2023). Canine as a Comparative and Translational Model for Human Mammary Tumor. Journal of Breast Cancer, 26(1), 1-13. https://doi.org/10.4048/jbc.2023.26.e4

Zhang, X., Flaws, J. A., Spinella, M. J., & Irudayaraj, J. (2023). The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease. Toxics, 11(1), Article 32. https://doi.org/10.3390/toxics11010032

Wang, J., Su, X., Jiang, L., Boudreau, M. W., Chatkewitz, L. E., Kilgore, J. A., Zahid, K. R., Williams, N. S., Chen, Y., Liu, S., Hergenrother, P. J., & Huang, X. (2023). Augmented Concentration of Isopentyl-Deoxynyboquinone in Tumors Selectively Kills NAD(P)H Quinone Oxidoreductase 1-Positive Cancer Cells through Programmed Necrotic and Apoptotic Mechanisms. Cancers, 15(24). https://doi.org/10.3390/cancers15245844

Kim, S., Yuan, J. B., Woods, W. S., Newton, D. A., Perez-Pinera, P., & Song, J. S. (2023). Chromatin structure and context-dependent sequence features control prime editing efficiency. Frontiers in Genetics, 14, Article 1222112. https://doi.org/10.3389/fgene.2023.1222112

Lichtor, T., Tang, B., & Roy, E. J. (2023). Cytokine Gene Vaccine Therapy for Treatment of a Brain Tumor. Brain Sciences, 13(11). https://doi.org/10.3390/brainsci13111505

Lim, C. K. W., Miskalis, A. J., Perez-Pinera, P., & Gaj, T. (2023). Delivering Base Editors In Vivo by Adeno-Associated Virus Vectors. In Methods in Molecular Biology (pp. 135-158). (Methods in Molecular Biology; Vol. 2606). Humana Press Inc.. https://doi.org/10.1007/978-1-0716-2879-9_11

Holdhoff, M., Nicholas, M. K., Peterson, R. A., Maraka, S., Liu, L. C., Fischer, J. H., Wefel, J. S., Fan, T. M., Vannorsdall, T., Russell, M., Iacoboni, M., Tarasow, T. M., Hergenrother, P. J., Dudek, A. Z., & Danciu, O. C. (2023). Phase I dose escalation study of procaspase-activating compound-1 (PAC-1) in combination with temozolomide in patients with recurrent high-grade astrocytomas. Neuro-Oncology Advances, 5(1), Article vdad087. https://doi.org/10.1093/noajnl/vdad087

Song, J. S., & Manjunath, M. (2023). Predicting the molecular functions of regulatory genetic variants associated with cancer. Oncotarget, 14, 775-777. https://doi.org/10.18632/oncotarget.28451

2022

Burke, M. D., Fan, T. M., Hergenrother, P. J., Brooke, C. B., Ranoa, D. R. E., Holland, R. L., Alnaji, F. G., Green, K. J., & Wang, L. (2022). Saliva-based Molecular Testing For SARS-CoV-2. (U.S. Patent No. 11530457).

Lim, C. K. W., McCallister, T. X., Saporito-Magriña, C., McPheron, G. D., Krishnan, R., Zeballos C, M. A., Powell, J. E., Clark, L. V., Perez-Pinera, P., & Gaj, T. (2022). CRISPR base editing of cis-regulatory elements enables the perturbation of neurodegeneration-linked genes. Molecular Therapy, 30(12), 3619-3631. https://doi.org/10.1016/j.ymthe.2022.08.008

Jain, I., Berg, I. C., Acharya, A., Blaauw, M., Gosstola, N., Perez-Pinera, P., & Underhill, G. H. (2022). Delineating cooperative effects of Notch and biomechanical signals on patterned liver differentiation. Communications biology, 5(1), [1073]. https://doi.org/10.1038/s42003-022-03840-9

Berry, M. R., Fadl-Alla, B. A., Samuelson, J., Rosol, T. J., & Fan, T. M. (2022). Investigating PSMA differential expression in canine uroepithelial carcinomas to aid disease-based stratification and guide therapeutic selection. BMC Veterinary Research, 18(1), [441]. https://doi.org/10.1186/s12917-022-03544-6

Ranoa, D. R. E., Holland, R. L., Alnaji, F. G., Green, K. J., Wang, L., Fredrickson, R. L., Wang, T., Wong, G. N., Uelmen, J., Maslov, S., Weiner, Z. J., Tkachenko, A. V., Zhang, H., Liu, Z., Ibrahim, A., Patel, S. J., Paul, J. M., Vance, N. P., Gulick, J. G., ... Burke, M. D. (2022). Mitigation of SARS-CoV-2 transmission at a large public university. Nature communications, 13(1), [3207]. https://doi.org/10.1038/s41467-022-30833-3

Tarasow, T., Peh, J., Hergenrother, P. J., & Boudreau, M. W. (2022). Cancer Therapy By Degrading Dual Mek Signaling. (U.S. Patent No. 11510919).

Nelczyk, A. T., Ma, L., Gupta, A. D., Gamage, H. E. V., McHenry, M. T., Henn, M. A., Kadiri, M., Wang, Y., Krawczynska, N., Bendre, S., He, S., Shahoei, S. H., Madak-Erdogan, Z., Hsiao, S. H., Saleh, T., Carpenter, V., Gewirtz, D. A., Spinella, M. J., & Nelson, E. R. (2022). The nuclear receptor TLX (NR2E1) inhibits growth and progression of triple- negative breast cancer. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1868(11), [166515]. https://doi.org/10.1016/j.bbadis.2022.166515

Gordon, D. L., Foreman, J. H., Connolly, S. L., Schnelle, A. N., Fan, T. M., & Barger, A. M. (2022). Acute phase protein concentrations following serial procaine penicillin G injections in horses. Equine veterinary journal. https://doi.org/10.1111/evj.13886

Ren, P., Tiede, C., Fanning, S. W., Adams, T., Speirs, V., Nelson, E. R., Cheng, C., Moore, T. W., Greene, G. L., Tomlinson, D., & Selvin, P. R. (2022). Labeling of a mutant estrogen receptor with an Affimer in a breast cancer cell line. Biophysical journal, 121(19), 3651-3662. https://doi.org/10.1016/j.bpj.2022.06.028

LeBlanc, A. K., Mazcko, C. N., Fan, T. M., Vail, D. M., Flesner, B. K., Bryan, J. N., Li, S., Wang, F., Harris, S., Vargas, J. D., Govindharajulu, J. P., Jaganathan, S., Tomaino, F., Srivastava, A. K., Chou, T. F., Stott, G. M., Covey, J. M., Mroczkowski, B., & Doroshow, J. H. (2022). Comparative Oncology Assessment of a Novel Inhibitor of Valosin-Containing Protein in Tumor-Bearing Dogs. Molecular Cancer Therapeutics, 21(10), 1510-1523. https://doi.org/10.1158/1535-7163.MCT-22-0167

Muñoz, K. A., & Hergenrother, P. J. (2022). Computational discovery of dynobactin antibiotics. Nature Microbiology, 7(10), 1512-1513. https://doi.org/10.1038/s41564-022-01234-5

Fan, T. M., Garrett, L. D., Selting, K. A., & Constable, P. D. (2022). Novel immunotherapy offers promising weapon against canine melanoma. American journal of veterinary research, 83(10). https://doi.org/10.2460/ajvr.22.08.0133

Parker, E. N., Cain, B. N., Hajian, B., Ulrich, R. J., Geddes, E. J., Barkho, S., Lee, H. Y., Williams, J. D., Raynor, M., Caridha, D., Zaino, A., Rohde, J. M., Zak, M., Shekhar, M., Muñoz, K. A., Rzasa, K. M., Temple, E. R., Hunt, D., Jin, X., ... Hergenrother, P. J. (2022). Erratum: An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with In Vivo Efficacy against Drug-Resistant Gram-Negative Infections (ACS Central Science (2022) 8:8 (1145-1158) DOI: 10.1021/acscentsci.2c00598). ACS Central Science, 8(9), 1362. https://doi.org/10.1021/acscentsci.2c00969

Parker, E. N., Cain, B. N., Hajian, B., Ulrich, R. J., Geddes, E. J., Barkho, S., Lee, H. Y., Williams, J. D., Raynor, M., Caridha, D., Zaino, A., Shekhar, M., Muñoz, K. A., Rzasa, K. M., Temple, E. R., Hunt, D., Jin, X., Vuong, C., Pannone, K., ... Hergenrother, P. J. (2022). An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with In Vivo Efficacy against Drug-Resistant Gram-Negative Infections. ACS Central Science, 8(8), 1145-1158. https://doi.org/10.1021/acscentsci.2c00598

Zhang, S., Leistico, J. R., Cho, R. J., Cheng, J. B., & Song, J. S. (2022). Spectral clustering of single-cell multi-omics data on multilayer graphs. Bioinformatics, 38(14), 3600-3608. https://doi.org/10.1093/bioinformatics/btac378

Kelly, A. M., Berry, M. R., Tasker, S. Z., McKee, S. A., Fan, T. M., & Hergenrother, P. J. (2022). Target-Agnostic P-Glycoprotein Assessment Yields Strategies to Evade Efflux, Leading to a BRAF Inhibitor with Intracranial Efficacy. Journal of the American Chemical Society, 144(27), 12367-12380. https://doi.org/10.1021/jacs.2c03944

Ma, L., Vidana Gamage, H. E., Tiwari, S., Han, C., Henn, M. A., Krawczynska, N., Dibaeinia, P., Koelwyn, G. J., Das Gupta, A., Bautista Rivas, R. O., Wright, C. L., Xu, F., Moore, K. J., Sinha, S., & Nelson, E. R. (2022). The Liver X Receptor Is Selectively Modulated to Differentially Alter Female Mammary Metastasis-associated Myeloid Cells. Endocrinology (United States), 163(7), [bqac072]. https://doi.org/10.1210/endocr/bqac072

Boyd, R. I., Ahmad, S., Singh, R., Fazal, Z., Prins, G. S., Erdogan, Z. M., Irudayaraj, J., & Spinella, M. J. (2022). Toward a Mechanistic Understanding of Poly-and Perfluoroalkylated Substances and Cancer. Cancers, 14(12), [2919]. https://doi.org/10.3390/cancers14122919

Boudreau, M. W., & Hergenrother, P. J. (2022). Evolution of 3-(4-hydroxyphenyl)indoline-2-one as a scaffold for potent and selective anticancer activity. RSC Medicinal Chemistry, 13(6), 711-725. https://doi.org/10.1039/d2md00110a

Barger, A., Baker, K., Driskell, E., Sander, W., Roady, P., Berry, M., Schnelle, A., & Fan, T. M. (2022). The use of alkaline phosphatase and runx2 to distinguish osteosarcoma from other common malignant primary bone tumors in dogs. Veterinary pathology, 59(3), 427-432. https://doi.org/10.1177/03009858221083035

Bhattacharjee, A., Johnson, E., Perez-Pinera, P., & Jensen, K. (2022). Development and Implementation of a Remote Enzyme Kinetics Laboratory Exercise. Journal of Microbiology and Biology Education, 23(1). https://doi.org/10.1128/jmbe.00286-21

Song, K., Minami, J. K., Huang, A., Dehkordi, S. R., Lomeli, S. H., Luebeck, J., Goodman, M. H., Moriceau, G., Krijgsman, O., Dharanipragada, P., Ridgley, T., Crosson, W. P., Salazar, J., Pazol, E., Karin, G., Jayaraman, R., Balanis, N. G., Alhani, S., Sheu, K., ... Graeber, T. G. (2022). Plasticity of Extrachromosomal and Intrachromosomal BRAF Amplifications in Overcoming Targeted Therapy Dosage Challenges. Cancer Discovery, 12(4), 1046-1069. https://doi.org/10.1158/2159-8290.CD-20-0936

Lowerison, M., Zhang, W., Chen, X., Fan, T., & Song, P. (2022). Characterization of Anti-Angiogenic Chemo-Sensitization via Longitudinal Ultrasound Localization Microscopy in Colorectal Carcinoma Tumor Xenografts. IEEE Transactions on Biomedical Engineering, 69(4), 1449 - 1460. https://doi.org/10.1109/TBME.2021.3119280

Hergenrother, P. J., & Riley, A. (2022). Topoisomerase inhibitors with antibacterial and anticancer activity. (U.S. Patent No. 11274106).

Boudreau, M. W., Mulligan, M. P., Shapiro, D. J., Fan, T. M., & Hergenrother, P. J. (2022). Activators of the Anticipatory Unfolded Protein Response with Enhanced Selectivity for Estrogen Receptor Positive Breast Cancer. Journal of Medicinal Chemistry, 65(5), 3894-3912. https://doi.org/10.1021/acs.jmedchem.1c01730

Zhang, L., Dutta, S., Xiong, S., Chan, M., Chan, K. K., Fan, T. M., Bailey, K. L., Lindeblad, M., Cooper, L. M., Rong, L., Gugliuzza, A. F., Shukla, D., Procko, E., Rehman, J., & Malik, A. B. (2022). Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants. Nature chemical biology, 18(3), 342-351. https://doi.org/10.1038/s41589-021-00965-6

Deng, H., Konopka, C. J., Prabhu, S., Sarkar, S., Medina, N. G., Fayyaz, M., Arogundade, O. H., Vidana Gamage, H. E., Shahoei, S. H., Nall, D., Youn, Y., Dobrucka, I. T., Audu, C. O., Joshi, A., Melvin, W. J., Gallagher, K. A., Selvin, P. R., Nelson, E. R., Dobrucki, L. W., ... Smith, A. M. (2022). Dextran-Mimetic Quantum Dots for Multimodal Macrophage Imaging In Vivo, Ex Vivo, and In Situ. ACS Nano, 16(2), 1999-2012. https://doi.org/10.1021/acsnano.1c07010

Vasan, A. K., Haloi, N., Ulrich, R. J., Metcalf, M. E., Wen, P. C., Metcalf, W. W., Hergenrother, P. J., Shukla, D., & Tajkhorshid, E. (2022). Role of internal loop dynamics in antibiotic permeability of outer membrane porins. Proceedings of the National Academy of Sciences of the United States of America, 119(8), [e2117009119]. https://doi.org/10.1073/pnas.2117009119

Svec, R. L., Mckee, S. A., Berry, M. R., Kelly, A. M., Fan, T. M., & Hergenrother, P. J. (2022). Novel Imidazotetrazine Evades Known Resistance Mechanisms and Is Effective against Temozolomide-Resistant Brain Cancer in Cell Culture. ACS chemical biology, 17(2), 299–313. https://doi.org/10.1021/acschembio.2c00022

Ma, L., Cho, W., & Nelson, E. R. (2022). Our evolving understanding of how 27-hydroxycholesterol influences cancer. Biochemical Pharmacology, 196, [114621]. https://doi.org/10.1016/j.bcp.2021.114621

Benoit-Lizon, I., Jacquin, E., Rivera Vargas, T., Richard, C., Roussey, A., Dal Zuffo, L., Martin, T., Melis, A., Vinokurova, D., Shahoei, S. H., Baeza Garcia, A., Pignol, C., Giorgiutti, S., Carapito, R., Boidot, R., Végran, F., Flavell, R. A., Ryffel, B., Nelson, E. R., ... Apetoh, L. (2022). CD4 T cell-intrinsic STING signaling controls the differentiation and effector functions of TH1 and TH9 cells. Journal for ImmunoTherapy of Cancer, 10(1), [e003459]. https://doi.org/10.1136/jitc-2021-003459

Shoaib, Z., Fan, T. M., & Irudayaraj, J. M. K. (2022). Osteosarcoma mechanobiology and therapeutic targets. British Journal of Pharmacology, 179(2), 201-217. https://doi.org/10.1111/bph.15713

Applegate, C. C., Deng, H., Kleszynski, B. L., Cross, T. W. L., Konopka, C. J., Dobrucki, L. W., Nelson, E. R., Wallig, M. A., Smith, A. M., & Swanson, K. S. (2022). Impact of administration route on nanocarrier biodistribution in a murine colitis model. Journal of Experimental Nanoscience, 17(1), 599-616. https://doi.org/10.1080/17458080.2022.2134563

Wen, Y., Rashid, F., Fazal, Z., Singh, R., Spinella, M. J., & Irudayaraj, J. (2022). Nephrotoxicity of perfluorooctane sulfonate (PFOS) - effect on transcription and epigenetic factors. Environmental Epigenetics, 8(1), [dvac010]. https://doi.org/10.1093/eep/dvac010

Cavalcanti, J. V. J., Selting, K. A., Ngo, M. T., Hoang, C. K. T., Schaeffer, D. J., Fan, T. M., Harley, B. A. C., & Phillips, H. (2022). Three-dimensional hydrogel culture systems support growth and determination of chemosensitivity of feline sarcoma and carcinoma cell lines. American journal of veterinary research, 83(6). https://doi.org/10.2460/ajvr.21.10.0157

Luo, M., Bao, L., Chen, Y., Xue, Y., Wang, Y., Zhang, B., Wang, C., Corley, C. D., McDonald, J. G., Kumar, A., Xing, C., Fang, Y., Nelson, E. R., Wang, J. E., Wang, Y., & Luo, W. (2022). ZMYND8 is a master regulator of 27-hydroxycholesterol that promotes tumorigenicity of breast cancer stem cells. Science Advances, 8(28), [abn5295]. https://doi.org/10.1126/sciadv.abn5295